Table 1 Patient characteristics
Number of patients | 59 |
Adults | 47 (80%) |
Children | 12 (20%) |
Clinical features | |
Sex ratio (M/F) | 36/23 |
Median age, years (range) | 36 (3.9–76.6) |
Extramedullary involvement | 12/48 (25%) |
Central nervous system involvement | 5/52 (9.6%) |
Laboratory features | |
Median initial WBC, G/L (range) | 45 (1.8–200) |
Median platelets count, G/L (range) | 44 (8–210) |
Median BM blasts percentage, % (range) | 53 (26–95) |
Cytogenetic features | |
Associated abnormalities | 20/52 (38%) |
Number abnormalities | |
Trisomy 22 | 8 |
Trisomy 8 | 2 |
Other | 6 |
Structure abnormalities | |
del(7q) | 3 |
Other | 8 |
Complex (≥3 abnormalities) | 6 |
Molecular features | |
FLT3 mutations | 8/40 (20%) |
ITD | 2 |
D835/I836 | 6 |
c-KIT mutations | 9/40 (22.5%) |
Exon 8 | 7 |
Exon 17 | 2 |
RAS mutations | 13/40 (32.5%) |
N-RAS | 11 |
K-RAS | 2 |
Isoforms of the CBFB-MYH11 fusion transcripts | |
A | 51 (86%) |
D | 1 (2%) |
E | 5 (8%) |
J | 2 (4%) |
