Table 1 Sensitivity, specificity and both positive and negative predictive values of the PCA-based classification approach for B-CLPD according to the expression of CD22, CD23, CD20, CD103, CD25, CD11c, CD43, CD79b, FMC7, CD24, CD34, CD5, sIgM, CD27, Cybcl2, CD10 and CD38 on neoplastic B-cells

From: Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping

Diagnostic Subgroups

Sensitivity

Specificity

Positive predictive value

Negative predictive value

Total B-CLL

91%

100%

100%

88%

 Typical B-CLL

99%

100%

100%

99%

 Atypical B-CLL

55%

100%

100%

89%

MCL

97%

96%

77%

99%

FL

92%

98%

85%

99%

Other

59%

94%

53%

96%

Total

89%

96%

89%

96%

  1. Abbreviations: B-CLPD, B-cell chronic lymphoproliferative diseases; B-CLL, B-cell chronic lymphocytic leukemia; MCL, mantle cell lymphoma; FL, follicular lymphoma; PCA, principal component analysis.