Figure 3 | Leukemia

Figure 3

From: LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway

Figure 3

LBH589 reduces tumors inoculated in SCID mice. HuT102 cells (107 per mouse) were injected subcutaneously into SCID mice. The mice (five per group) were treated with either vehicle or LBH589. Treatment was initiated on the day after inoculation. Tumor volume and weight were monitored on the indicated days after the injection of cells. (a) Serial changes in tumor volume in treated and untreated mice. Data are the mean±s.d. for five mice each. Mann–Whitney’s U-test was used to compare results with control values. (b) Tumors removed from untreated mice and LBH589-treated mice on day 28 after cell inoculation were weighed. (c) Immunohistochemical staining shows the acetylation of histones H3/H4 in tumors of treated mice. (d) TUNEL assays show apoptotic cells in tumors from mice treated with LBH589 compared with the control mice. Magnification, × 40.

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