Table 2 Summary of results in human precursor-B ALL xenograft model
Mouse number | % Blasts in blood smear | % Blasts in bone marrow aspirate | Liver infiltration | hCD10 in bone marrow |
|---|---|---|---|---|
Untreated | ||||
1 | 0 | 8–11 | + | +++ |
2 | 0 | 3–6 | ++ | + |
3 | 4–6 | 39–44 | − | ++ |
4 | ND | ∼100 | +++ | +++ |
5 | 0–1 | 2 | + | + |
6 | 0 | 2 | − | + |
7 | 51–56 | ∼100 | +++ | +++ |
8 | 41–43 | ∼100 | +++ | +++ |
9 | 8–10 | 41–46 | ++ | +++ |
10 | 12–15 | 39–43 | ++ | ++ |
11 | 0 | 0–1 | + | + |
GSI-I treated | ||||
1a | 0 | 0 | − | − |
2 | 41–45 | ∼100 | +++ | +++ |
3a | 0 | 0 | − | − |
4 | 1–3 | 6–11 | ++ | +++ |
5a | 0 | 0 | − | − |
6 | 3–6 | ND | ++ | + |
7 | 8–11 | ND | ++ | ++ |
8 | 19–22 | 56–58 | +++ | +++ |
9a | 0 | 0 | − | − |
10a | 0 | 0 | − | − |
11 | 8–12 | 44–46 | +++ | +++ |
12a | 0 | 0 | − | − |
