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Acute Leukemias

Allogeneic cord blood transplantation for adult acute lymphoblastic leukemia: retrospective survey involving 256 patients in Japan

Leukemia volume 26, pages 1482–1486 (2012)Cite this article

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Abstract

We investigated the efficacy of cord blood transplantation (CBT) for adult acute lymphoblastic leukemia (ALL) by reviewing medical records of 256 patients reported to the Japan Cord Blood Bank Network between June 1997 and August 2006. Cumulative incidence of neutrophil engraftment at day 100 was 78%. Infused CD34-positive cell dose (>1 × 105 cells/kg) was associated with successful neutrophil engraftment. Cumulative incidence of grade II–IV acute graft-versus-host disease (GVHD) at day 100 was 37%. A 2-year disease-free and overall survival (OS) rates were 36% and 42%, respectively. Multivariate analysis showed that age (51 or older vs younger than 50) (hazard ratio 1.9, 95% confidence interval (CI), 1.3–2.8, P=0.001), disease status (non-remission vs remission) (hazard ratio 2.2, 95% CI, 1.5–3.2, P<0.0001), grade III–IV acute GVHD (hazard ratio 2.0, 95% CI, 1.2–3.2, P=0.006) and absence of chronic GVHD (hazard ratio 2.4, 95% CI, 1.1–5.1, P=0.02) were negatively associated with OS. CBT is effective for some patients with advanced ALL. It is worth considering for further evaluation.

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Acknowledgements

This work was supported by a Research Grant on Tissue Engineering (H17-14) and a Research Grant for Allergic Disease and Immunology (H20-015) from the Ministry of Health, Labor and Welfare of Japan.

Author contribution

TM designed the research and wrote the manuscript. TY analyzed the data. MK, KY, EK, STaniguchi, STakahashi, MO and HS performed the research. HA, MT, HK, SKai and TI-N managed the data. KK and SKato took the leadership of authors.

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Authors and Affiliations

  1. Division of Social Communication System, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    T Matsumura, M Kami & E Kusumi

  2. Division of Medical Statistics, Graduate School of Medicine, University of Tohoku, Sendai, Japan

    T Yamaguchi

  3. Department of Internal Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    K Yuji

  4. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    S Taniguchi

  5. Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    S Takahashi

  6. Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    M Okada

  7. Division of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    H Sakamaki

  8. Hokkaido Cord Blood Bank, Sapporo, Japan

    H Azuma

  9. The Metro Tokyo Red Cross Cord Blood Bank, Tokyo, Japan

    M Takanashi

  10. Tokyo Cord Blood Bank, Tokyo, Japan

    H Kodo

  11. Hyogo Cord Blood Bank, Nishinomiya, Japan

    S Kai

  12. Japan Cord Blood Bank Network, Tokyo, Japan

    T Inoue-Nagamura & K Kato

  13. Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan

    S Kato

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  1. T Matsumura
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  2. M Kami
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  3. T Yamaguchi
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  6. S Taniguchi
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  16. S Kato
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Correspondence to T Matsumura.

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Matsumura, T., Kami, M., Yamaguchi, T. et al. Allogeneic cord blood transplantation for adult acute lymphoblastic leukemia: retrospective survey involving 256 patients in Japan. Leukemia 26, 1482–1486 (2012). https://doi.org/10.1038/leu.2012.11

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