Figure 1

(a) OS from second randomization by TRAC-assay-guided (hashed line) vs protocol-guided arm (solid line). (b) OS by in vitro sensitivity to the given second-line treatment (sensitive=solid line, intermediate=hashed line, resistant=hashed/dotted line). (c) OS from first randomization by in vitro sensitivity to the randomized treatment (sensitive=solid line, intermediate=hashed line, resistant=hashed/dotted line).