Figure 2 | Leukemia

Figure 2

From: Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1

Figure 2

The optimal peptide sequence of mHag UTA2-1 is 9-mer QLLNSVLTL. (a) A mHag− EBV-LCL was loaded with 9-mer peptides holding the substituted leucine in a concentration of 10 μM and tested for recognition by CTL 503A1 with IFN-γ ELISA. Only peptide sequence QLLNSVLTL was recognized and consequently identified as mHag UTA2-1. As a positive control, mHag+ EBV-LCL was used. (b) Similarly, mHag UTA2-1 (QLLNSVLTL) and the allelic peptide (QLPNSVLTL) were exogenously loaded on the mHag− EBV-LCL in various concentrations and tested for recognition by 503A1 with IFN-γ ELISA.

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