Figure 3 | Leukemia

Figure 3

From: Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia

Figure 3

Synergistic effect of LBH589 with vincristine and dexamethasone in a human ALL mouse model of T-ALL. (a) Treatment schedule in mice engrafted with human ALL-T1 cells. (b) Fluorescence-activated cell sorting (FACS) analysis of T-ALL human blasts in PB at different times after transplantation. (*P=0.026). (c) Spleen size at killing in mice from control group, LBH589, vincristine and dexamethasone or with the three-drug combination. (d) Western blot analysis of acetylated H3 and H4 acetylation and H2A.X phosphorylation in leukemic cells from spleen after LBH589 treatment. (e) Heat map of hypermethylated and hypomethylated genes (red and green, respectively) in leukemic cells from spleen of mice treated with LBH589 or control mice. (f) Kaplan–Meier survival curves of leukemic mice after treatment with LBH, vincristine and dexamethasone, or with the combination of LBH with vincristine and dexamethasone.

Back to article page