Table 1 Cytogenetic, immunophenotyping and methylation pattern of cells from patients used for the characterization of the ALL mice model
Sample | Karyotype | Immunophenotype | Percentage of blasts in patients' sample | Methylation pattern |
|---|---|---|---|---|
ALL-T1 | 46, XX, del(1)(p32)?, del(6)(q23)?,t(11;14)(p13;q11) | CD3− CD7+ CD2+ CD5+ CD4+/− (60%) CD3CITO+ CD34− CD10– CD1A− TDTlo+ | >80% | 325 Hypermethylated genes 49 Hypomethylated genes |
ALL-B1 | 36,X,–Y,–2,–3,–4,–5,der(6q),–7,–9,–10,–14,–15,–16,–17,–18,–20,–22,+4 mar | CD45lo/verylo+ CD19+ CD34+(60%) CD38hi+ CD22+ CD10– CD20−(12%) TdT+(89%) CD3cito− CD7− CD2− CD5− CD1a− CD8− CD4− CD56− MPO− CD33− CD13− CD117− CD15lo+CD11b− CD11c− CD14− GlicoforineA– CD61− CD41a− CD42b− CD36− | 98.40% | 879 Hypermethylated genes 73 Hypomethylated genes |
