Table 2 The 2- and 5-year cumulative AML incidences with mortality as the competing risk and with left truncation, and the 2- and 5-year OS probabilities with left truncation

From: Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis

Cumulative AML incidences, % (95% CI)

Lenalidomide-treated

Untreated

Overall population

(n =295)

(n =125)

 Two-year

6.9 (3.3–13.9)

12.1 (7.0–20.3)

 Five-year

22.8 (17.1–30.3)

19.9 (12.9–30.0)

Patients with WHO-defined isolated del(5q) a

(n =160)

(n =85)

 Two-year

6.6 (2.5–16.7)

7.4 (3.1–16.9)

 Five-year

18.1 (11.3–28.1)

16.9 (9.4–29.4)

OS probabilities, % (95% CI)

Lenalidomide-treated

Untreated

Overall population

(n =295)

(n =125)

 Two-year

89.9 (84.1–96.0)

74.4 (66.1–83.7)

 Five-year

53.7 (46.6–61.9)

40.5 (30.9–53.1)

Patients with WHO-defined isolated del(5q) a

(n =160)

(n =85)

 Two-year

93.5 (87.5–99.9)

76.1 (66.4–87.1)

 Five-year

60.2 (51.1–71.0)

44.4 (32.8–60.3)

  1. Abbreviations: AML, acute myeloid leukemia; CI, confidence interval; OS, overall survival; WHO, World Health Organization.
  2. aDefined as patients who had isolated del(5q) and <5% bone marrow blasts.