Table 1 Overview about all investigated TPGs

From: The MLL recombinome of acute leukemias in 2013

Direct TPG

Infant

Pediatric

Adult

Total

 

ALL

AML

Other

ALL

AML

Other

ALL

AML

Other

 

AFF1/AF4

216

2

4

97

2

2

274

3

600

MLLT3/AF9

73

23

2

37

73

3

6

71

3

291

MLLT1/ENL

96

1

2

40

10

1

37

12

199

MLLT10/AF10

22

28

2

4

40

1

1

20

2

120

ELL

18

19

1

29

1

68

PTD

2

1

64

1

68

MLLT4/AF6

1

3

5

19

6

33

67

EPS15

12

1

1

4

3

1

4

26

MLLT11/AF1Q

7

4

2

13

SEPT9

2

5

5

12

SEPT6

3

6

2

11

MLLT6/AF17

1

2

7

10

NA

9

3

1

2

3

  

1

 

19

AFF3/LAF4

2

3

5

TET1

1

2

2

5

PICALM

1

1

1

1

4

ABI1

1

2

3

CASC5

1

2

3

MYO1F

3

3

SEPT5

1

1

1

3

ACTN4

1

1

2

FLNA

2

2

FOXO3

2

2

CEP170B

2

2

MAML2

2

2

SEPT11

1

1

2

TNRC18

1

1

2

ABI2

1

1

ACACA

1

1

AFF4/AF5

1

1

AKAP13

1

1

AP2A2

1

1

ARHGEF12

1

1

ARHGEF17

1

1

BCL9L

1

1

BUD13

1

——

1

C2CD3

1

1

CASP8AP2

1

1

CBL

1

1

CEP164

1

1

CREBBP

1

1

DCP1A

1

1

DCPS

1

1

FNBP1

1

1

GAS7

1

1

GMPS

1

1

KIAA1524

1

1

LAMC3

1

1

LOC100131626

1

1

BTBD18

1

1

ME2

1

1

MYH11

1

1

NEBL

1

1

NRIP3

1

1

PDS5A

1

1

PRPF19

1

1

RUNDC3B

1

1

EEFSEC/SELB

1

1

SEPT2

1

1

SMAP1

1

1

TOP3A

1

1

VAV1

1

1

1p13.1

1

1

1p32 (EPS15)

1

1

2

9p13.3

1

1

9p22 (MLLT3/AF9)

1

1

11q23

2

2

11q23.3

1

1

11q24

1

1

21q22

1

1

Xq26.3 (CT45A2)

1

1

Sum

440

105

13

205

202

9

333

272

11

1590

  1. Abbreviations: ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; DCAL, Diagnostic Center of Acute Leukemia.
  2. All fusion genes that have been analyzed at the DCAL and their distribution between infant, pediatric and adult leukemia patients are shown. Total numbers are given for each patient group separate in ALL, AML and other diseases. The most frequent fusion partner genes were separated from the gene that has been isolated less frequently.