Table 1A Comparison of MVD, kep and Ktrans among patients with MGUS, SMM and MM

From: Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial

 

MGUS (n=10)

SMM (n=10)

MM (n=7)

P

MVD

15 (15–19.7)

19.4 (7.6–32.5)

20.9 (10.5–37.6)

0.008

k ep

3.9 (1.6–9.2)

9 (0.7–12.2)

5.8 (2.1–12.7)

0.15

K trans

2.4 (1–4.2)

2.3 (0.4–4.4)

3.1 (1.6–4.1)

0.33

  1. Abbreviations: MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; MVD, microvessel density; SMM, smoldering MM.
  2. MVD was estimated by determining the average number of CD34-stained microvessels in 10 areas of maximal MVD counted at a high-power field (h.p.f.; × 500 magnification). Large vessels and vessels in the periosteum or bone were excluded. Areas of staining with no discrete breaks were counted as a single vessel. The presence of a lumen was not required. The MVD results were expressed as average number of microvessels per h.p.f. Three patients with MM did not undergo bone marrow biopsies and were not included in this analysis.
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