Figure 4

Development of a novel prognostic risk classification. (a) Kaplan–Meier estimates of OS in months (m) for four groups according to Model-1 in the training cohort. Three-year OS for low, intermediate, high and very high-risk groups amounts to 95.2, 69.3, 32.8 and 5.3%, respectively. (b) Kaplan–Meier estimates of OS for four groups according to Model-2 in the training cohort. Three-year OS for low, intermediate, high and very high-risk groups amounts to 83.3, 66.4, 39.7 and 9.5%, respectively. (c) Kaplan–Meier estimates of OS for five groups according to IPSS-R in the training cohort. Three-year OS for very low, low, intermediate, high and very high-risk groups amounts to 88.2, 73.9, 51.9, 45.3 and 19.6%, respectively. (d) Kaplan–Meier estimates of OS for four groups according to Model-1 in the validation cohort. Three-year OS for low, intermediate, high and very high-risk groups amounts to 88.3, 84.4, 55.7 and 22.8%, respectively. (e) Kaplan–Meier estimates of OS for four groups according to Model-2 in the validation cohort. Three-year OS for low, intermediate, high and very high-risk groups amounts to 83.3, 77.0, 64.1 and 33.3%, respectively. (f) Kaplan–Meier estimates of OS for five groups according to IPSS-R in the validation cohort. Three-year OS was 83.3, 93.7, 59.3 and 57.1% for the very low, low, intermediate and high-risk groups. For the very high-risk group, the median OS was 9.2 months, as 3-year OS was not applicable.