Table 1 Demographic data, peripheral blood parameters, MDS subtypes, results of cytogenetics and risk classification according to IPSS/IPSS-R for the total cohort
From: Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
Parameter | Total cohort (n=944) |
|---|---|
Patient numbers (ratios, ranges or percentages) | |
Demographic characteristics | 944 |
Males:females (ratio) | 580:364 (1.6) |
Median age (years) | 72.8 (23.3–90.8) |
<50 | 46 (4.9%) |
50–<60 | 81 (8.6%) |
60–<70 | 240 (25.4%) |
70–<80 | 423 (44.8%) |
⩾80 | 154 (16.3%) |
Cases with follow-up | 875 |
Median follow-up in months | 32.3 |
Median OS in months | 54.5 |
MDS subtypes (WHO, 2008) | 944 |
RA | 41 (4.3%) |
RARS | 81 (8.6%) |
RARS-T | 28 (3.0%) |
RCMD | 195 (20.7%) |
RCMD-RS33 | 183 (19.4%) |
RAEB-1 | 191 (20.7%) |
RAEB-2 | 188 (19.9%) |
MDS with isolated 5q-deletion | 37 (3.9%) |
Cytogenetics | 944 |
Normal karyotype | 648 (68.6%) |
Aberrant karyotype | 296 (31.4%) |
IPSS risk group | 848 |
Low | 324 (38.2%) |
Intermediate-1 | 319 (37.6%) |
Intermediate-2 | 171 (20.2%) |
High | 34 (4.0%) |
IPSS-R risk group | 848 |
Very low | 122 (14.4%) |
Low | 340 (40.1%) |
Intermediate | 203 (23.9%) |
High | 130 (15.3%) |
Very high | 53 (6.3%) |
