Figure 3
The core transcriptional program classifies human AML: (a) 18 of 26 genes (80%) from the BET-responsive core signature were differentially expressed across a cohort of 436 AML patients as shown in the heat map. The gene set could classify this cohort into six groups through the use of unsupervised clustering. (b) Significant differences in cytogenetic characteristics were shown for individuals in each of the groups (P<0.0001), with significant differences in molecular prognostic factors including mutational status for (c) NPM1c and FLT3-ITD (Supplementary Figure 3) also noted (P=0.02 and P=0.02, respectively). (+8=trisomy 8, NK=normal karyotype, Other HR=other high risk (t(6;9), 3q abnormality and del 5q).
