Table 1 Kinases not targeted by volasertib at concentrations up to 10 μmol/l
From: Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
Abl | MAPKAP-K2 |
|---|---|
AMPK | MEK1 |
Aurora A | Met |
Aurora B | MKK1 |
Axl | MSK1 |
B-RAF | Nek6 |
Btk | p38a |
Cdk1/B1 | p38b |
Cdk2/E | p38d |
CHK1 | p38g |
CK1 | PAK2 |
CK2 | PDGFRa |
C-RAF | PDGFRb |
CSK | PDK1 |
DYRK1A | PI3Ka |
ECK | PKA |
ErbB4 | PKBa |
ERK2 | PKBb |
FGFR1 | PKCa |
FGFR3 | PRAK |
FLT1 | Ret |
FLT3 | ROCK2 |
GSK3β | Ron |
Hek | S6K |
HER2 | SGK |
HGFR | Src |
ITK | βIRK |
JAK2 | Syk |
JAK3 | Tie2 |
JNK1 | VEGFR1 |
Lck | VEGFR3 |
Lyn |
