Table 2 Individualized asparaginase dose adjustments based on nadir serum asparaginase levels on the adult DFCI ALL Consortium Protocol

From: Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia

NSAA (IU/ml)

Change in subsequent asparaginase doses

<0.025

Increase by 80%a from most recent dose

0.025 to <0.05

Increase by 60%

0.05 to <0.08

Increase by 40%

0.08 to <0.1

Increase by 20%

0.1 to <0.14

No change

0.14 to <0.20

Decrease by 20%

>0.20

Decrease by 40%

  1. Abbreviations: ALL, acute lymphoblastic leukemia; NSAA, nadir serum asparaginase activity.
  2. aPercentage change from most recent dose. Starting dose 12 500 IU/m2. Minimum dose 6000 IU/m2. Maximum dose 25 000 IU/m2.
Back to article page