Table 1 List of significant deregulated pathways in cell lines obtained using IPA

From: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

TF1

SKM1

K562

HEL

Selenoamino acid metabolism

Estrogen-mediated S-phase entry

AMPK signaling

Estrogen-mediated S-phase entry

Mitochondrial dysfunction

Pentose phosphate pathway

HMGB1 signaling

Cyclins and cell cycle regulation

AMPK signaling

Cell cycle: G1/S checkpoint regulation

mTOR signaling

PI3K signaling in B lymphocytes

Regulation of eIF4 and p70S6K signaling

Small-cell lung cancer signaling

Polyamine regulation in colon cancer

mTOR signaling

mTOR signaling

Lysine biosynthesis

Cell cycle regulation by BTG family proteins

Breast cancer regulation by stathmin1

Role of NANOG in mammalian embryonic stem cell pluripotency

Actin cytoskeleton signaling

ILK signaling

Purine metabolism

Cyclins and cell cycle regulation

Chronic myeloid leukemia signaling

Cyclins and cell cycle regulation

Glioma signaling

Polyamine regulation in colon cancer

Glioma signaling

Ceramide signaling

Aldosterone signaling in epithelial cells

Assembly of RNA polymerase II complex

Assembly of RNA polymerase III complex

ErbB signaling

fMLP signaling in neutrophils

 

Signaling by Rho family GTPases

TNFR1 signaling

Cell cycle: G1/S checkpoint regulation

  

Glucocorticoid receptor signaling

Non-small cell lung cancer signaling

  

Glycine, serine and threonine metabolism

Growth hormone signaling

  

Role of CHK proteins in cell cycle checkpoint control

Small-cell lung cancer signaling

  

VDR/RXR activation

Protein ubiquitination pathway

  

Lysine degradation

Nitric oxide signaling in the cardiovascular system

  

Tight junction signaling

AMPK signaling

  

Ubiquinone biosynthesis

Glioblastoma multiforme signaling

  

Mitotic roles of polo-like kinase

 
  

Wnt/β-catenin signaling

 
  

PI3K/AKT signaling

 
  

Renal cell carcinoma signaling

 
  

Regulation of eIF4 and p70S6K signaling

 
  

TNFR2 signaling

 
  

Fructose and mannose metabolism

 
  

Telomerase signaling

 
  1. Gene expression profiling was performed in all four cell lines with SF3B1 knockdown, and genes showing >2-fold change were used for the analysis.