Table 3 Pathway analysis (IPA) of the significant differentially expressed genes between SF3B1 mutant and wild type obtained using edgeR
Ingenuity canonical pathways | P-value | Ratio | Molecules |
|---|---|---|---|
Lymphotoxin β receptor signaling | 0.00074131 | 9.68E−02 | NFKBID, BCL2L1, CASP3, RELB, CXCL1 and TRAF1 |
Agranulocyte adhesion and diapedesis | 0.001071519 | 5.73E−02 | CXCL3, PODXL2, CCL4,CLDN19, CXCL14, CXCL1, CCL3L1/CCL3L3, MMP2, CXCL2, MYH7B and CCL4L1/CCL4L2 |
Heme biosynthesis II | 0.001096478 | 1.67E−01 | FECH, ALAS2, CPOX and HMBS |
Hepatic fibrosis/hepatic stellate cell activation | 0.00162181 | 5.81E−02 | CXCL3, LEPR, IL6R, MMP2, LBP, IL6, MYH7B, AGTR1 and PGF |
Communication between innate and adaptive immune cells | 0.001995262 | 6.25E−02 | CCL4, TLR7, CCL3L1/CCL3L3, CD83, IGHG1, IGHA1 and IL6 |
Colorectal cancer metastasis signaling | 0.003467369 | 4.48E−02 | BCL2L1, ADCY9, CDH1, JUN, CASP3, PTGER3, DIRAS3, IL6R, TLR7, MMP2, IL6 and PGF |
IL-17A signaling in fibroblasts | 0.004570882 | 1E−01 | NFKBID, JUN, IL6 and NFKBIZ |
Toll-like receptor signaling | 0.004570882 | 7.81E−02 | JUN, TLR7, TNFAIP3, LBP and TRAF1 |
Differential regulation of cytokine production in macrophages and T-helper cells by IL-17A and IL-17F | 0.004786301 | 1.67E−01 | CCL4, CXCL1 and IL6 |
Granulocyte adhesion and diapedesis | 0.007762471 | 4.95E−02 | CXCL3, CCL4, CLDN19, CXCL14, CXCL1, CCL3L1/CCL3L3, MMP2, CXCL2 and CCL4L1/CCL4L2 |
Airway pathology in chronic obstructive pulmonary disease | 0.009772372 | 1.82E−01 | CXCL3 and MMP2 |
TNFR2 signaling | 0.016595869 | 8.82E−02 | JUN, TNFAIP3 and TRAF1 |
Heme bosynthesis from uroporphyrinogen-III I | 0.018620871 | 1.82E−01 | FECH and CPOX |
Aryl hydrocarbon receptor signaling | 0.024547089 | 4.09E−02 | TGM2, CCNE1, GSTM2, ALDH1A1, JUN, NQO2 and IL6 |
NRF2-mediated oxidative stress response | 0.025118864 | 4.1E−02 | GSR, JUN, GSTM2, NQO2, DNAJC6, JUND, FOSL1 and ABCC4 |
Role of IL-17A in psoriasis | 0.025703958 | 1.43E−01 | CXCL3 and CXCL1 |
Gα12/13 signaling | 0.028840315 | 4.72E−02 | BTK, CDH7, CDH1, JUN, MEF2D and CDH11 |
Tetrapyrrole biosynthesis II | 0.029512092 | 1.43E−01 | ALAS2 and HMBS |
CDK5 signaling | 0.033884416 | 5.15E−02 | FOSB, PPP1CC, ADCY9, PPM1J and EGR1 |
CD40 signaling | 0.033884416 | 5.63E−02 | JUN, TNFAIP3, MAPKAPK2 and TRAF1 |
Mitotic roles of polo-like kinase | 0.041686938 | 5.41E−02 | PLK3, PPM1J, ANAPC13 and CCNB1 |
Adenine and adenosine salvage III | 0.042657952 | 1.18E−01 | PNP and ADAT3 |
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | 0.046773514 | 1.11E−01 | HAAO and KYNU |
T-helper cell differentiation | 0.047863009 | 5.56E−02 | STAT4, IL6R, IL6 and RORC |
