Table 4 Top ranking genes showing differential exon usage between SF3B1 mutant and control, obtained from RNA sequencing data analysis using DEXSeq

From: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

Gene ID

Exon ID

Gene name

Chromosome

Strand

P-value

Padj

FC

ENSG00000125354

E011

SEPT6

X

−1

1.67E−78

5.19E−73

0.822522658

ENSG00000111843

E006

TMEM14C

6

1

2.80E−51

4.36E−46

0.803897136

ENSG00000131669

E006

NINJ1

9

−1

1.09E−33

1.13E−28

0.835812796

ENSG00000088986

E014

DYNLL1

12

1

1.21E−28

9.43E−24

0.913566493

ENSG00000223865

E018

HLA-DPB1

6

1

3.05E−27

1.90E−22

1.357267219

ENSG00000101019

E025

UQCC1

20

−1

1.71E−26

8.88E−22

0.889537433

ENSG00000132199

E025

ENOSF1

18

−1

2.57E−24

1.14E−19

0.905515696

ENSG00000125991

E049

ERGIC3

20

1

4.11E−23

1.42E−18

0.870728412

ENSG00000101019

E024

UQCC1

20

−1

2.01E−22

6.25E−18

0.878172451

ENSG00000118495

E010

PLAGL1

6

−1

2.78E−22

7.85E−18

1.753766932

ENSG00000266086

E005

RP11-159D12.5

17

−1

1.43E−18

3.43E−14

1.051487592

ENSG00000119777

E023

TMEM214

2

1

1.35E−18

3.43E−14

0.724952987

ENSG00000130066

E011

SAT1

X

1

2.63E−17

5.83E−13

1.224469811

ENSG00000101019

E029

UQCC1

20

−1

3.49E−17

7.24E−13

0.987866168

ENSG00000141425

E015

RPRD1A

18

−1

2.14E−16

3.91E−12

1.151614234

ENSG00000268400

E058

CTD-3214H19.4

19

1

2.08E−16

3.91E−12

0.720165623

ENSG00000127586

E055

CHTF18

16

1

2.45E−16

4.24E−12

0.83461565

ENSG00000130066

E015

SAT1

X

1

4.80E−16

7.86E−12

1.112053709

ENSG00000160789

E072

LMNA

1

1

1.00E−15

1.56E−11

0.74131183

ENSG00000130066

E010

SAT1

X

1

1.22E−15

1.81E−11

1.175909464

ENSG00000119777

E024

TMEM214

2

1

6.13E−15

8.66E−11

0.769414939

ENSG00000266086

E004

RP11-159D12.5

17

−1

1.51E−14

2.04E−10

1.073999383

ENSG00000168675

E009

LDLRAD4

18

1

4.10E−14

5.10E−10

0.882283199

ENSG00000160789

E071

LMNA

1

1

6.34E−14

7.58E−10

0.907377148

ENSG00000214021

E019

TTLL3

3

1

1.13E−13

1.30E−09

1.027729333

ENSG00000196576

E041

PLXNB2

22

−1

1.59E−13

1.77E−09

0.53703246

ENSG00000166508

E021

MCM7

7

−1

2.21E−13

2.37E−09

1.034956343

ENSG00000114770

E040

ABCC5

3

−1

2.75E−13

2.79E−09

1.290748901

ENSG00000196365

E028

LONP1

19

−1

2.78E−13

2.79E−09

0.876937237

ENSG00000130066

E002

SAT1

X

1

3.59E−13

3.49E−09

0.967812734

ENSG00000102119

E017

EMD

X

1

3.76E−13

3.55E−09

1.050545479

ENSG00000130066

E014

SAT1

X

1

5.55E−13

5.08E−09

1.168469304

ENSG00000266086

E006

RP11-159D12.5

17

−1

5.72E−13

5.08E−09

1.073091463

ENSG00000055609

E005

KMT2C

7

−1

6.09E−13

5.26E−09

1.089688525

ENSG00000228315

E065

GUSBP11

22

−1

6.70E−13

5.63E−09

1.125912723

ENSG00000156860

E023

FBRS

16

1

7.27E−13

5.95E−09

1.10075677

ENSG00000268400

E071

CTD-3214H19.4

19

1

8.37E−13

6.67E−09

1.139015436

ENSG00000214021

E065

TTLL3

3

1

1.15E−12

8.34E−09

1.269221488

ENSG00000122566

E004

HNRNPA2B1

7

−1

1.10E−12

8.34E−09

1.160615984

ENSG00000101557

E035

USP14

18

1

1.13E−12

8.34E−09

1.043528763

  1. Genes are ranked by adjusted P-value (Padj).
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