Table 5 Top ranking genes showing differential exon usage between SF3B1 mutant and wild type, obtained from RNA sequencing data analysis using DEXSeq

From: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

Gene ID

Exon ID

Gene name

Chromosome

Strand

P-value

Padj

FC

ENSG00000125354

E011

SEPT6

X

−1

9.38E−92

3.53E−86

0.827252395

ENSG00000132199

E025

ENOSF1

18

−1

5.10E−33

9.59E−28

0.911519852

ENSG00000189283

E004

FHIT

3

−1

1.73E−28

2.18E−23

3.663047029

ENSG00000101019

E025

UQCC1

20

−1

9.24E−28

8.69E−23

0.72317914

ENSG00000111843

E006

TMEM14C

6

1

9.84E−26

7.40E−21

0.91596329

ENSG00000125991

E049

ERGIC3

20

1

9.81E−23

6.15E−18

0.791616483

ENSG00000071082

E025

RPL31

2

1

3.50E−21

1.88E−16

0.717351893

ENSG00000101019

E029

UQCC1

20

−1

2.62E−20

1.23E−15

0.701671242

ENSG00000211644

E016

IGLV1-51

22

1

3.99E−20

1.67E−15

0.441359946

ENSG00000088986

E014

DYNLL1

12

1

5.65E−20

2.12E−15

0.845893878

ENSG00000028310

E077

BRD9

5

−1

3.97E−18

1.36E−13

0.767361674

ENSG00000127586

E055

CHTF18

16

1

2.12E−17

6.64E−13

0.878313474

ENSG00000101019

E007

UQCC1

20

−1

3.20E−17

9.25E−13

1.47227241

ENSG00000160710

E024

ADAR

1

−1

1.30E−16

3.51E−12

1.320985378

ENSG00000101019

E024

UQCC1

20

−1

2.02E−16

5.06E−12

0.71746253

ENSG00000118495

E010

PLAGL1

6

−1

4.10E−16

9.65E−12

2.538692764

ENSG00000255863

E017

AC073610.5

12

−1

1.20E−15

2.65E−11

0.882954589

ENSG00000211644

E017

IGLV1-51

22

1

1.38E−15

2.88E−11

0.485819764

ENSG00000075218

E014

GTSE1

22

1

2.48E−15

4.91E−11

1.468605485

ENSG00000137133

E004

HINT2

9

−1

2.09E−14

3.93E−10

0.839329231

ENSG00000205593

E031

DENND6B

22

−1

5.28E−14

9.46E−10

4.609575952

ENSG00000101019

E013

UQCC1

20

−1

1.05E−13

1.74E−09

2.895712194

ENSG00000101019

E026

UQCC1

20

−1

1.11E−13

1.74E−09

0.732192837

ENSG00000101019

E028

UQCC1

20

−1

1.10E−13

1.74E−09

0.698206407

ENSG00000103426

E028

CORO7-PAM16

16

−1

1.21E−13

1.83E−09

0.838759667

ENSG00000205593

E030

DENND6B

22

−1

3.43E−13

4.97E−09

4.61396886

ENSG00000101019

E010

UQCC1

20

−1

4.54E−13

6.33E−09

1.74387423

ENSG00000111640

E017

GAPDH

12

1

8.37E−13

1.12E−08

1.387332969

ENSG00000100387

E034

RBX1

22

1

1.24E−12

1.61E−08

1.875629945

ENSG00000271270

E006

TMCC1-AS1

3

1

2.12E−12

2.66E−08

2.979442225

ENSG00000028310

E078

BRD9

5

−1

3.00E−12

3.64E−08

0.795339192

ENSG00000101019

E027

UQCC1

20

−1

3.26E−12

3.84E−08

0.703747197

ENSG00000255103

E077

KIAA0754

1

1

3.38E−12

3.85E−08

1.663519412

ENSG00000268400

E035

CTD-3214H19.4

19

1

3.57E−12

3.95E−08

1.463054031

ENSG00000205593

E032

DENND6B

22

−1

4.28E−12

4.60E−08

4.764064117

ENSG00000136044

E042

APPL2

12

−1

5.63E−12

5.88E−08

0.720698938

ENSG00000101019

E005

UQCC1

20

−1

1.00E−11

9.92E−08

1.53637968

ENSG00000167323

E043

STIM1

11

1

9.97E−12

9.92E−08

0.766910234

ENSG00000101019

E016

UQCC1

20

−1

1.35E−11

1.28E−07

2.2692562

ENSG00000161013

E025

MGAT4B

5

−1

1.36E−11

1.28E−07

1.097105348

  1. Genes are ranked by adjusted P-value (Padj).