Figure 4 | Leukemia

Figure 4

From: A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies

Figure 4

Immunostaining of formalin-fixed, paraffin-embedded BM biopsies from fibrotic PMF patients with the mouse monoclonal antibody CAL2. The megakaryocytes in the case with genotypically demonstrated CALR mutation are strongly labelled. The fibres are not labelled (a; magnification: x250). The megakaryocytes of cases without a CALR mutation remained unlabelled (b; magnification: x250). The CALR mutation status was confirmed by Sanger sequencing.

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