Table 1 Risk to childhood acute lymphoblastic leukemia at loci 10q26.13 and 12q23.1

From: A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1

rs35837782 (10q26.13, LHPP)

Case genotypes

Control genotypes

OR

95% CI

P-value

 

RAF

AA

AG

GG

RAF

AA

AG

GG

   

UK-GWAS

0.67

93

358

373

0.62

745

2510

1945

1.27

(1.14–1.41)

2.04 × 10−5

German-GWAS

0.67

93

365

376

0.63

268

952

804

1.19

(1.05–1.36)

0.0072

Meta

        

1.24

(1.14–1.34)

6.04 × 10−7

UK replication 1

0.67

73

211

251

0.62

150

475

405

1.19

(1.03–1.39)

0.022

UK replication 2

0.67

56

265

253

0.61

167

497

391

1.33

(1.14–1.55)

0.0002

German replication

0.65

184

607

621

0.63

204

701

574

1.13

(1.02–1.26)

0.0203

Meta

        

1.20

(1.11–1.29)

3.66 × 10−6

Combined meta

        

1.21

(1.15–1.28)

1.38 × 10−11 (Phet=0.48, I2=0%)

rs4762284 (12q23.1, ELK3)

RAF

AA

AT

TT

RAF

AA

AT

TT

OR

95% CI

P-value

UK-GWAS

0.33

373

358

94

0.30

2578

2160

462

1.18

(1.05–1.32)

0.0046

German-GWAS

0.33

372

366

95

0.28

1072

773

179

1.30

(1.14–1.49)

1.01 × 10−4

Meta

        

1.23

(1.13–1.34)

2.87 × 10−6

UK replication 1

0.31

258

227

52

0.30

497

408

98

1.03

(0.88–1.21)

0.6870

UK replication 2

0.34

232

287

52

0.29

534

434

85

1.30

(1.11–1.53)

0.0008

German replication

0.31

650

625

124

0.28

746

619

109

1.15

(1.02–1.29)

0.0178

Meta

        

1.16

(1.07–1.25)

3.85 × 10−4

Combined meta

        

1.19

(1.12–1.26)

8.41 × 10−9 (Phet=0.17, I2=38%)

  1. Abbreviations: CI, confidence interval; GWAS, genome-wide association study; OR, odds ratio; RAF, risk allele frequency.
  2. Risk allele for rs35837782 is G and risk allele for rs4762284 is T.
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