Figure 5

Enhanced efficacy to glucocorticoids in chemorefractory AML patient samples revealed by ex vivo drug testing. (a, b) The DSS of dexamethasone, methylprednisolone and prednisolone were compared between diagnostic and relapsed samples in 1064 and 1145 AML patient cases using two-tailed student’s t-test. (c) The drug testing was performed with 66 relapsed and refractory samples from 48 AML patients treated with cytarabine containing chemotherapy. The DSS of dexamethasone, methylprednisolone and prednisolone were normalized against 15 healthy bone marrow samples and quantified as selective DSS. Each data point represents drug response from individual patient sample. (d) Dexamethasone responses were compared between AML patient samples carrying FLT3 wild-type (n=19) and point and/or ITD mutation (n=10) using Mann–Whitney U-test.