Table 1 Baseline characteristics stratified by the protocol applied

From: High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study)

Characteristics

R-MPL (N=69)

R-MP (N=38)

All (N=107)

Median age (range), years

73 (66–85)

73 (66–85)

73 (66–85)

Female

34 (49.3)

16 (42.1)

50 (46.7)

Karnofsky performance status a

 Median (range)

70 (30–100)

60 (30–100)

70 (30–100)

70%

32 (56.1)

17 (47.2)

49 (52.7)

Lymphoma lesions b

 Single

28 (41.2)

13 (34.2)

41 (38.7)

 Multiple

40 (58.8)

25 (65.8)

65 (61.3)

Lymphoma location

 Infratentorial

11 (16.2)

10 (26.3)

21 (19.8)

 Supratentorial

50 (73.5)

20 (52.6)

70 (66.0)

 Both

7 (10.3)

8 (21.1)

15 (14.2)

Serum lactate dehydrogenase c

 Elevated

30 (44.8)

17 (45.9)

47 (45.2)

 Normal

37 (55.2)

20 (54.1)

57 (54.8)

Ocular involvement

1 (1.5)

0 (0)

1 (0.9)

Histology

 DLBCL

69 (100.0)

38 (100.0)

107 (100.0)

  1. Abbreviations: DLBCL, diffuse large B-cell lymphoma; R-MP, rituximab, methotrexate and procarbazine; R-MPL, rituximab, methotrexate, procarbazine and lomustine.
  2. Numbers are frequencies (proportions) unless specified otherwise.
  3. aKarnofsky performance status missing in 12 patients.
  4. bMissing in 1 patient.
  5. cMissing in 2 patients.