Figure 5

γδ T-ALL cells are more susceptible than αβ T-ALL to apoptosis induced by CX-4945. Flow cytometry analysis of the survival (Annexin-V/7-AAD staining) of (a) γδ (n=5) and αβ (n=5) T-cell blast samples (obtained from T-ALL patients and expanded in NSG mice) or (b) γδ (PEER) or αβ (MOLT-4) T-ALL cell lines, cultured for the indicated times with increasing concentrations of CX-4945 (T-test, *P<0.05; ***P<0.001).