Figure 5 | Leukemia

Figure 5

From: Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

Figure 5

Differential gene expression of WT1-28z/IL-12 CAR T cells compared with WT1-28z CAR T cells when stimulated with OVCAR3 tumor cells for 48 hs. (a) Heat map of statistically significant (P⩽0.05) differential gene expression of cytokines between four normal donor T cells expressing WT1-28z/IL-12 CAR or WT1-28z CAR. (b) Heat map of statistically significant (P⩽0.05) differential expression of genes involved in chemokine or chemotaxis functions between four normal donor T cells expressing WT1-28z/IL-12 CAR or WT1-28z CAR. (c) Heat map of statistically significant (P⩽0.05) genes showing a distinct transcriptional profile between four normal donor T cells expressing WT1-28z/IL-12 CAR or WT1-28z CAR.

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