Table 1 Comparison of biochemical and hematological properties of AE9a versus AE9aNT as revealed in the study
AE9a | AE9aNT | Figure | |
|---|---|---|---|
CBFβ interaction | Yes | No | 1b/2 |
SHARP-SPOC interaction | Yes | Yes | 3a/3d/S3a |
Transactivation capacitya | Yes | No | 3b/S3b |
AML target genes | Affected | Affected | 3f |
Notch target genes | Strongly affected (derepressed)b | Less affected (repressed)b | 3f/S6c |
Serial replating capacity | Increased | Slightly increased | 4a |
cKit+ | Elevated | Less elevated | 5b/5c, right |
WBC | Elevated | As controls | 5c, left/S6a |
Survival | Reduced | As controls | 5a, left |
Disease initiation | Yes | No | 5 |
Stem cell and progenitor pool | N. a.c | Increased | 6c |
B-cells (B220+) | Reduced | Elevated | 6a |
T-cells (CD3+) | Reduced | Reduced | 6b |
