Figure 4 | Leukemia

Figure 4

From: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups

Figure 4

Non-coding mutations confirmed experimentally with ChIP-seq and ATAC-seq. Diagrams of non-coding mutations in three genes and the corresponding annotation data. All lower panels; correlation of mutation loci with H3K27Ac and ATAC-seq signal of CLL110 and ChromHMM annotation (all three layers obtained from experiments with primary CLL cells) and layered H3K27Ac data from the ENCODE database (GM12878). (a) IKZF3 locus and surrounding region on chromosome 17, with the position of all mutations detected in our cohort, (b) SAMHD1 locus and surrounding region on chromosome 20, with the position of all mutations detected in our cohort and (c) BIRC3 locus and surrounding region on chromosome 11, with the position of all mutations detected in our cohort.

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