Figure 6 | Leukemia

Figure 6

From: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups

Figure 6

Mutation signature analysis. (a) Three mutation signatures identified across 46 patients using non-negative matrix factorisation (NMF). (b) Correlations between signatures identified in 46 patients and the corresponding age, or proportion of mutated canonical AID or APOBEC sites per subtracted somatic sample. Blue lines=regression lines, and P-values from the glm. (c) Proportions of mutation signatures from Alexandrov (2013),29,43 where Sig.1B corresponds to Alexandrov Signature 1B, and so on, and signatures found across 46 patients.

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