Figure 3
From: SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
SETD2 protein and H3K36Me3 levels in HMC-1.1 and -1.2 cell lines before and after inhibition of proteasome-mediated degradation. (a) SETD2 and H3K36Me3 levels as detected by western blotting in HMC-1.1 and HMC-1.2 cells compared to K562 cells. (b and c) Effect of proteasome inhibition by bortezomib on SETD2 and H3K36Me3 levels in HMC-1.1 and HMC-1.2. One of three independent experiments is shown in all panels.
