Table 1 Overview about all investigated TPGs

From: The MLL recombinome of acute leukemias in 2017

#

Direct TPG

Infant

Pediatric

Adult

Total

  

ALL

AML

Other

ALL

AML

Other

ALL

AML

Other

 

1

AFF1/AF4

338

4

10

139

3

10

332

3

839

2

MLLT3/AF9

113

40

5

56

132

3

9

90

1

449

3

MLLT1/ENL

154

2

4

56

21

1

50

14

302

4

MLLT10/AF10

39

43

2

12

66

1

1

33

197

5

PTD

6

1

98

2

107

6

ELL

24

1

24

1

45

2

97

7

MLLT4/AF6

1

2

16

28

9

38

1

95

8

EPS15

16

1

1

6

5

4

5

38

9

MLLT11/AF1Q

1

13

7

2

23

10

no der(11)

14

6

1

3

5

  

2

 

31

11

SEPT6

5

10

2

17

12

MLLT6/AF17

1

2

11

14

13

SEPT9

2

5

6

13

14

AFF3/LAF4

3

5

8

15

TET1

1

2

3

6

16

11q23.3

1

1

2

1

5

17

SEPT5

1

1

2

1

5

18

ABI1

2

2

4

19

KNL1

2

2

4

20

MAML2

2

1

1

4

21

MYO1F

3

1

4

22

PICALM

1

1

1

1

4

23

TNRC18

1

2

1

4

24

FLNA

2

1

3

25

NEBL

1

1

1

3

26

ACTN4

1

1

2

27

AFF4/AF5

2

2

28

BTBD18

2

2

29

CBL

1

1

2

30

CEP170B

2

2

31

CREBBP

2

2

32

DCP1A

1

1

2

33

FOXO3A

2

2

34

KIAS1524

2

2

35

SEPT11

1

1

2

36

ABI2

2

2

37

ACACA

1

1

38

ACER1

1

1

39

AKAP13

1

1

40

AP2S2

1

1

41

ARHGAP26

1

1

42

ARHGEF12

1

1

43

ARHGEF17

1

1

44

BCL9L

1

1

45

BUD13

1

1

46

C2CD3

1

1

47

CASP8AP2

1

1

48

CEP164

1

1

49

CLTA

1

1

50

CLTC

1

1

51

CT45S2

1

1

52

DCPS

1

1

53

EEFSEC

1

1

54

FNBP1

1

1

55

GAS7

1

1

56

GIGYF2

1

57

GMPS

1

1

58

KIF2A

1

1

59

LAMC3

1

1

60

LOC100131626

1

1

61

ME2

1

1

62

MKL1

1

1

63

MYH11

1

1

64

NOX4

1

1

65

NRIP3

1

1

66

NUP153

1

1

67

PDS5A

1

1

68

PFDN4

1

1

69

PRPF19

1

1

70

PRRC1

1

1

71

RABGAP1

1

1

72

RUNDC3B

1

1

73

SEPT2

1

1

74

SMAP1

1

1

75

TCF12

1

1

76

TOP3A

1

1

77

VAV1

1

1

78

1p13.1

1

1

79

6q27

1

1

80

9p13.3

1

1

81

11q24.3

1

1

82

21q22

1

1

83

MLL internal inv

1

1

 

SUM

692

160

24

313

339

19

415

373

10

2345

  1. Abbreviations: AML, acute lymphoblastic leukemia; AML, acute myeloid leukemia; DCAL, Diagnostic Center of Acute Leukemia; TPG, translocation partner gene.
  2. All fusion genes that have been analyzed at the DCAL and their distribution between infant, pediatric and adult leukemia patients are shown. Total numbers are given for each patient group separated in ALL, AML and other diseases. The most frequent fusion partner genes were separated from the other genes that have been isolated less frequently by a line. Genes marked in bold represent out-of-frame MLL–X fusions.