Figure 3
From: The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms
Altered EC TPO/MPL signaling affects the vascular niche function in Tie2/FF1 mice. (a) MPL expression was significantly increased in both arterial marrow ECs and sinusoidal marrow ECs of the Tie2/FF1 recipients compared to control mice. Gene expression is shown as the fold-change compared with the control marrow EC expression which was set as ‘1’. (b) The expression levels of CXCL12 and SCF in WT marrow ECs, MPL+/− marrow ECs and MPL−/− marrow ECs were measured using real-time qPCR. Gene expression in MPL+/− marrow ECs, and MPL−/− marrow ECs is shown as the relative fold-change compared with WT EC expression which was set as ‘1’.
