Figure 5
Genomic-guided therapeutic opportunities of the DLBCL cohort. Therapeutic opportunities have been classified according to the level of evidence supporting the effect of the genomic biomarker into (i) clinical guidelines (for example, FDA-approved or NCNN recommendations), (ii) late (phases III–IV) or (iii) early (phases I–II) clinical trials, (iv) case reports or (v) preclinical data. In addition to the alterations described as biomarkers of drug response in DLBCL (biomarker and tumor match), we included driver mutations in genes described as biomarkers of drug response in DLBCL upon a different amino acid change (biomarker match of different gene mutation), as well as genomic alterations described as biomarkers of drug response in other tumor types (biomarker match and tumor repurposing). (a) This panel depicts the therapeutic opportunities per patient (each patient has been counted only once according to their best therapeutic option following the above classification). (b) This panel depicts the therapeutic opportunities per gene; the numbers on top of the bars correspond to the number of patients exhibiting a biomarker of drug response in that gene (each patient has been counted only once according to their best therapeutic option given the gene alteration). Biomarkers that have been described for DLBCL and other non-Hodgkin lymphomas were also considered in the tumor match category. (c) Finally, this panel depicts the contribution of each alteration type to the overall number of in silico prescriptions per patient and altered gene.
