Figure 5 | Leukemia

Figure 5

From: Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

Figure 5

TKI increases the glycosylation of FLT3-ITD. Western blot analysis of FLT3 or phospho-FLT3 (130 and 160 kDa) and α-tubulin (50 kDa) in whole-cell lysates with or without AC220 and/or 2-DG (2-deoxy-D-glucose) of (a) Ba/F3 cells transduced with empty vector, FLT3-WT or indicated FLT3 mutant construct, (b) AML cell lines, (c) PDX cells and (d) MV4-11 cells.

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