Table 1 Classification of FLT3-mutated AML cell lines and PDX cells into FLT3 genotype categories: heterozygous FLT3-ITD and FLT3-LOH

From: Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

AML cell lines/PDX cells

FLT3 genotype

ITD type

ITD insertion sequence

MOLM-13

Heterozygous

Y631F(7)

F(Y)DFREYE/YDLK

PL-21

Heterozygous

569/570(42)

FKSVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKNGM

AML-573

Heterozygous

E604D(21)

D(E)PSDNEYFYVDFREYEYDLKW/EFPR

AML-640

Heterozygous

L610F(28)

F(L)GSSDNEYFYVDFREYEYDLKWEFPREN/LEFG

  

F612V(20)

V(F)DFREYEYDLKWEFPRENLE/FGKV

MV4-11

LOH

H633L(10)

H(L)VDFREYEYD/LKWE

AML-415

LOH

E598D(6)

D(E)FREYE/EYDL

AML-579

LOH

E598Y(8)

Y(E)VDFREYE/EYDL

  1. Abbreviations: FLT3, fms-related tyrosine kinase 3; ITD, internal tandem duplication; LOH, loss of heterozygosity; PDX, patient-derived xenograft. Underlined amino acids are inserted before the ITD.
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