Figure 4
From: Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma
Identification of VAV1 mutations in human AITL and PTCL-NOS. (a) Schematic diagram of VAV1–STAP2 fusion genes. (b) Structure of VAV1 mutations and VAV1 functional domains. (c) Confirmation of VAV1 mutations by Sanger sequencing. Arrows indicate where mutations occur. (d) Mutation profile of RHOA and VAV1 mutations. Three slushed samples had RHOA mutations other than typical c.G50T mutations. In PTCL 216, c.50_51GA>TC mutations resulted in p.Gly17Val alternation; in PTCL 223, c.50G>A mutation resulted in p.Gly17Glu alternation; and in PTCL 198, c.49_50GG>TT mutations resulted in p.Gly17Leu alternation. *, tatgeted sequencing for VAV1 was not performed.
