Figure 5
From: Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma
Effect of Src inhibitors on VAV1–STAP2 activation. (a–c) Jurkatmock, JurkatWTVAV1 and JurkatVAV1–STAP2 cells were stimulated with or without anti-CD3 antibody followed by anti-mouse IgG antibody. Cells were treated with (b) PP2 or (c) dasatinib at indicated concentrations. Lysates were fractionated and immunoblotted with antibodies to VAV1, phospho VAV1, and PLCγ1. β-Actin served as loading control. p-PLCγ1, phospho PLCγ1; p-VAV1, phospho VAV1.
