Figure 4 | Leukemia

Figure 4

From: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

Figure 4

PI3-K signalling upregulates BATF3 in HRS cells. (a) GO analysis of genes regulated by PI3-K signalling in primary HRS cells (GSE12453(ref. 31) or GSE39133(ref. 32) data or both; total of 137 upregulated and 443 downregulated genes) revealed enrichment of several functions including ‘transcription initiation from RNA polymerase II promoter’. (b) Comparison of genes regulated by PI3-K signalling in primary HRS cells with a comprehensive set of TFs revealed the upregulation of 12 TFs and the downregulation of 47 TFs by PI3-K signalling in HRS cells.

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