Table 2 Distribution of aberrant (aPC) and normal (nPC) plasma cells in BM samples from MM patients in VGPR, CR and sCR with discrepant MRD results (MRD⁺ vs MRD⁻) by NGF vs conventional flow-MRD assays

Case ID	Disease status	Conventional flow			NGF
		% tPC	% nPC	% aPC	% tPC	% nPCs	% aPC
1	CR	0.01	0.01	0	0.008	0.007	0.0004
2	CR	0.01	0.01	0	0.02	0.02	0.0002
3	CR	0.007	0.007	0	0.007	0.007	0.0003
4	CR	0.04	0.04	0	0.02	0.02	0.0004
5	sCR	0	0	0	0.003	0.002	0.0006
6	CR	0.1	0.1	0	0.1	0.1	0.002
7	CR	0.2	0.2	0	0.2	0.2	0.02
8	sCR	0	0	0	0.002	0.003	0.0002
9	CR	0.9	0.9	0	0.6	0.6	0.005
10	CR	0.2	0.2	0	0.06	0.06	0.0004
11	VGPR	0	0	0	0.01	0.01	0.0007
12	CR	0	0	0	0.01	0.01	0.006
13	sCR	0.2	0.2	0	0.2	0.2	0.005
14	sCR	0.03	0.03	0	0.03	0.03	0.002
15	CR	0.1	0.1	0	0.07	0.04	0.03
16	VGPR	0	0	0	0.009	0.008	0.001
17	CR	0.1	0	0	0.004	0.003	0.001
18	CR	0.04	0	0	0.01	0.01	0.0002
19	CR	0.09	0.08	0.01	0.05	0.05	0
20	CR	0.1	0.1	0.006	0.1	0.1	0
21	CR	0.4	0.3	0.02	0.3	0.3	0

Abbreviations: aPC, aberrant plasma cell; BM, bone marrow; CR, complete response; MM, multiple myeloma; MRD, minimal residual disease; NGF, next generation flow; nPC, normal plasma cell; sCR, stringent CR; tPC, total plasma cells; VGPR, very good partial response.

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