Figure 2
Convergent mutational evolution (CME) in CLL driver genes. (a) Bar plots of the percentage of mutated cases carrying one or more mutations in each gene. The Ph on the KLHL6 bar denotes that multiple mutations in this gene are mainly identified in the same allele (that is, phased events). (b) Graphical representation of ATM (CLL296) and BCOR (CLL385 and CLL335) mutations identified in three different patients. The CCF of each mutation is represented as a dot and the intervals show the sequencing variability. Histogram (bottom) shows the number of CME events with mutations at similar CCFs, different CCFs or both. (c) Patterns of CME in the longitudinal analysis. Representation of two cases in which mutations conferring CME for NOTCH1 and TP53, respectively, are acquired at different time points (left), and two cases with stable CME (that is, similar CCF of the mutations in the two samples analyzed) for SF3B1, and NOTCH1 and ATM, respectively (right).
