Figure 4

CCF-based patterns with prognostic impact. (a) Time to first treatment (TTFT) or overall survival (OS) curves of some representative mutated genes that follow a CCF-independent (top), CCF-gradual (middle) or CCF-dominant pattern (bottom) with impact on the outcome of the patients. The cutoff obtained by maxstat is shown on the top of the curves included in the CCF-dominant pattern. P-values for all pairwise comparisons are shown inside the plot areas. P, P-values by Gray’s test (TTFT) or log-rank test (OS). (b) Heat map of the co-occurrence of the driver alterations identified in ⩾10 cases and IGHV mutational status by representing the adjusted P-value (Q-value) of the Fisher’s exact test. Mutated genes with clinical impact in the univariate analysis are depicted in bold.