Figure 5
Role of the subclonal architecture and mutational complexity in CLL evolution. (a) Boxplots of the number of driver alterations in patients with or without a subclonal driver alteration (left). Boxplots dividing the group of patients with a subclonal driver present in three groups regarding their clonality: cases with clonal and subclonal, subclonal-high and only subclonal-low alterations (right). (b) Comparison of TTFT between patients carrying 0, 1, 2, 3 or ⩾4 driver alterations in the subgroup of patients with subclonal (left) or clonal tumors (right). (c) Survival curves according to the number of driver alterations in the subgroup of patients carrying subclonal (left) or clonal tumors (right).
