Figure 1 | Leukemia

Figure 1

From: RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia

Figure 1

Frequency and distribution of RAS pathway mutations in pediatric BCP-ALL. (a) Overview of all clonal or subclonal mutations found in pediatric BCP-ALL cases at initial diagnosis. Top bar represents the cytogenetic subtype. Black boxes represent clonal mutations (variant allele frequency (VAF)⩾25%) and gray boxes represent subclonal mutations (VAF <25%). (b) Frequency of clonal and subclonal RAS pathway mutations overall and within the cytogenetic subtypes. BA, BCR-ABL1-rearranged; BAL, BCR-ABL1-like; BO, B-other; ER, ETV6-RUNX1-rearranged; HD, high hyperdiploid; MLL, t(4;11)-rearranged; TCF3, TCF3-PBX1-rearranged. (c) Co-occurrence of RAS pathway mutations: bar heights indicate the frequency of mutated cases carrying the number of RAS pathway mutations indicated on the x-axis. Segmentation of each bar indicates the distribution of mutated genes.

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