Figure 5
(a) Description of the rationale for investigation of expression of the receptors of all cytokines modulated miR-29b in MM cells. (b) Evaluation of the expression of the receptors of the main miR-29b modulated chemokines and cytokines on MM cells according to data set GSE47552 (general scatter plots and plots of receptors that significantly differ between HDs (HD) and MM patients). *P<0.05. (c) Scatter plots and Kaplan–Meier curves with log-rank test results of the chemokine/cytokine receptors able to significantly discriminate PFS, overall survival (OS) and patients presenting bone disease (BL) as compared with patients that do not present lytic lesions (No BL) in the coMMpass trial. For survival analysis, patients were grouped into high and low expression groups according to the median value of receptor expression (FPKM). *P<0.05.
