Table 1 Main effects induced by miR-29b enforced expression in DCs

From: MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells

Affected function

Effects

Traslational relevance

DC maturation

↓ CD83/86 double-positive mature DCs

 

Production and secretion of cytokines and chemokines

↓ IL-23, CCL2, CXCL10, IL1β, MIP1α IL8, CCL8, CCL7, CXCL2

 

Chemotaxis

↓ Capability of DCs to attract CCR2+ pro-inflammatory monocytes

Impairment and recover of the inflammatory-immunosuppressive human BM milieu, which strongly contribute to MM progression, bone disease and immune escape

Th17 polarization and expansion

↓ IL-23

↓ RORc, IL-17A

↓ Th17

 

Pro-inflammatory molecular networks

↓ NF-κB, STAT3, MAP2K4

↑ SOCS1

 

Inflammasome machinery

↓ Caspase1, BIRC3

 

Angiogenesis

↓ Ability to develop tube-like structures

Reduction of MM cell growth and extramedullary dissemination

Survival signaling in MM co-cultured with DCs

↓ ERK, AKT, SRC

↑ P-21, c-PARP

Decrease in MM cells proliferation

Genetic instability in MM co-cultured with DCs

↓ p ATM, pATR, CHK1, CHK2, H2AX

Reduction of inflammation-related DNA damage and potentially of mutations responsible for tumor progression, drug resistance and immune escape

  1. Abbreviations: BM, bone marrow; DC, dendritic cell; IL-23, interleukin-23; MM, multiple myeloma; NF-κB, nuclear factor-κB; SOCS1, suppressor of cytokine signaling 1; STAT3, signal transducer and activator of transcription 3.
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