Figure 4
Measuring cytoplasmic and RNA incorporation rates of AZA and 5-AZA-CdR following in vivo therapy. (a) Bar graphs representing mean abundance measurements of unincorporated AZA in the cytoplasm of bone marrow CD34− cells of AZA responders (n=4, green) and nonresponders (n=3, orange) at different time points during AZA therapy. Whiskers represent s.d., and *P-value <0.05, Student’s t-test. Individual patient measurements are shown on the right. (b) Mean abundance measurements of unincorporated 5-AZA-CdR in the cytoplasm of bone marrow CD34− cells of AZA responders (n=4, green) and nonresponders (n=3, orange). Whiskers represent s.d., and *P-value <0.05, Student’s t-test. Individual patient measurements are shown on the right. (c) Mean abundance measurements of RNA-incorporated AZA in bone marrow CD34− cells of AZA responders (n=4, green) and nonresponders (n=4, orange). Whiskers represent s.d., and *P-value <0.05, Student’s t-test. Individual patient measurements are shown on the right.
