Figure 1 | Leukemia

Figure 1

From: Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines

Figure 1

APOBEC contribution in plasma cell dyscrasias. (a, b) Barplot of absolute (a) and relative (b) contribution of mutational signatures on three different MM WES series. (c, d) Extraction of mutational signature from 18 HMCLs: (c) unsupervised hierarchical clustering, showing two main clusters A and B characterized by different APOBEC contribution. (d) Barplot representing the absolute APOBEC contribution to the mutational load when NNMF was applied considering clusters A and B as independent series. Asterisks (*) highlight cell lines with ‘canonical’ t(14;16) translocations (IGH/MAF). The template (§) and hash (#) signs mark cell lines carrying alternative MAF/MAFB rearrangements among clusters A and B, respectively. (e, f) Boxplot showing the progressive increase of the APOBEC absolute (e) and relative (f) mutation load from MGUS to Cluster A HMCLs.

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