Figure 8
From: The contribution of PARs to inflammation and immunity to fungi
Cross talk between PARs and TLRs in inflammation to fungi. Shown is a proposed model in which inflammation is promoted by PAR1 and PAR2 activation in response to Candida and by PAR2 inhibition in response to Aspergillus. This occurs by TLR regulation of PAR signaling, with TLR2 promoting PAR1 activity, and TLR4 suppressing PAR2 activity. Thus, the exploitation or subversion of distinct TLR/PAR-dependent pathways contributes to divergence in the promotion of inflammatory response in fungal infections. PAR, protease-activated receptor; TLR, Toll-like receptor.
