Table 1 Comparison of percentages of viable CD3+ cells expressing intracellular cytokines in normal cervix and HGCIN

From: Evolving immunosuppressive microenvironment during human cervical carcinogenesis

Cytokine

Normal % (±s.d.) N =8

HGCIN % (±s.d.) N =9

P -value

Unactivated

 IFN-γ

2.3 (±1.5)

8.6 (±9.5)

0.03

 TGF-β

4.0 (±2.9)

10.2 (±8.0)

0.03

Activated a

 IFN-γ

16.0 (±12)

30.4 (±12.7)

0.02

 TGF-β

5.9 (±3.5)

12.3 (±7.9)

(0.08)

  1. Abbreviations: IFN-γ, interferon-γ; HGCIN, high-grade CIN; PMA, phorbol 12-myristate 13-acetate; TGF-β, transforming growth factor-β.
  2. aTreated with PMA and ionomycin as described in Methods.
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